Title : Defects in base excision repair combined with elevated intracellular dCTP levels dramatically reduce mutation induction in yeast by ethyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine.

Pub. Date : 1998

PMID : 9776180






2 Functional Relationships(s)
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1 Defects in base excision repair combined with elevated intracellular dCTP levels dramatically reduce mutation induction in yeast by ethyl methanesulfonate and N-methyl-N"-nitro-N-nitrosoguanidine. Ethyl Methanesulfonate cut up Drosophila melanogaster
2 Previously, we determined that elimination of deoxycytidylate (dCMP) deaminase (DCD1) in the yeast Saccharomyces cerevisiae increases the intracellular dCTP:dTTP ratio and reduces the induction of G x C --> A x T transitions in the SUP4-o gene by ethyl methanesulfonate (EMS) and N-methyl-N"-nitro-N-nitrosoguanidine (MNNG). Ethyl Methanesulfonate cut up Drosophila melanogaster