Pub. Date : 1998 Oct 23
PMID : 9774447
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | To decipher the upstream signals for paclitaxel-induced transcriptional activation and cell death, we studied the involvement of protein kinases that lead to the activation of AP-1, specifically the c-Jun NH2-terminal kinase (JNK1), p38, and the extracellular signal-regulated kinase 1 (ERK1). | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
2 | Paclitaxel-induced IL-8 promoter activation was inhibited by dominant-inhibitory mutants of JNK, p38, and the super-repressor form of IkappaBalpha, but not by dominant-inhibitory forms of ERK1. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |