Pub. Date : 1998 Oct 23
PMID : 9774447
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK). | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK). | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Paclitaxel activated JNK, and to a lesser degree p38, but not ERK1. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Paclitaxel-induced IL-8 promoter activation was inhibited by dominant-inhibitory mutants of JNK, p38, and the super-repressor form of IkappaBalpha, but not by dominant-inhibitory forms of ERK1. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Dominant-inhibitory mutants of JNK1 also greatly reduced paclitaxel-induced cell death, and the kinetics of JNK induction was closely followed by DNA fragmentation. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Dominant-inhibitory mutants of JNK1 also greatly reduced paclitaxel-induced cell death, and the kinetics of JNK induction was closely followed by DNA fragmentation. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | These results indicate (i) that paclitaxel activates the JNK signaling pathway and (ii) that JNK activation is a common point of paclitaxel-induced gene induction and cell death. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | These results indicate (i) that paclitaxel activates the JNK signaling pathway and (ii) that JNK activation is a common point of paclitaxel-induced gene induction and cell death. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |