Title : The effect of renin-angiotensin system inhibitors on pro- and anti-inflammatory cytokine production.

Pub. Date : 1998 Jul

PMID : 9767420






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1 The results reported in the present study show that modulators of the renin-angiotensin system, such as the angiotensin-converting enzyme (ACE)-inhibitor captopril and the angiotensin II receptor type I antagonist valsartan, have potent inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines tumour necrosis factor (TNF) and interleukin-1 (IL-1) in vitro. Captopril renin Homo sapiens