Title : Lisinopril, an angiotensin I-converting enzyme inhibitor, prevents entry of murine hematopoietic stem cells into the cell cycle after irradiation in vivo.

Pub. Date : 1998 Oct

PMID : 9766448






3 Functional Relationships(s)
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1 Lisinopril, an angiotensin I-converting enzyme inhibitor, prevents entry of murine hematopoietic stem cells into the cell cycle after irradiation in vivo. Lisinopril angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus
2 In the present paper, we report on the in vivo effect of lisinopril, an ACE inhibitor, on the proliferative status of murine hematopoietic stem cells triggered into S-phase by irradiation. Lisinopril angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus
3 Administration of lisinopril (10 mg/kg) 1 hour after irradiation led to a 90 to 100% inhibition of murine plasma ACE activity as observed during the first 4 hours postirradiation. Lisinopril angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 Mus musculus