Title : HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers.

Pub. Date : 1998 Oct

PMID : 9765513






2 Functional Relationships(s)
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1 We examined the effects of the calcium channel blockers nitrendipine, diltiazem, verapamil, bepridil, and mibefradil on the cloned HERG and KvLQT1/IsK K+ channels. Bepridil potassium voltage-gated channel subfamily Q member 1 Homo sapiens
2 Similarly, KvLQT1/IsK is inhibited by bepridil (EC50 = 10.0 microM) and mibefradil (EC50 = 11.8 microM), while being insensitive to nitrendipine, diltiazem, or verapamil. Bepridil potassium voltage-gated channel subfamily Q member 1 Homo sapiens