Pub. Date : 1998 Oct 5
PMID : 9763421
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The presence of PtdIns(3)P in fab1 mutants, combined with previous data, indicate that PtdIns(3,5)P2 synthesis is a two step process, requiring the production of PtdIns(3)P by the Vps34p PtdIns 3-kinase and the subsequent Fab1p- dependent phosphorylation of PtdIns(3)P yielding PtdIns(3,5)P2. | phosphatidylinositol 3-phosphate | phosphatidylinositol 3-kinase VPS34 | Saccharomyces cerevisiae S288C |
| 2 | The presence of PtdIns(3)P in fab1 mutants, combined with previous data, indicate that PtdIns(3,5)P2 synthesis is a two step process, requiring the production of PtdIns(3)P by the Vps34p PtdIns 3-kinase and the subsequent Fab1p- dependent phosphorylation of PtdIns(3)P yielding PtdIns(3,5)P2. | phosphatidylinositol 3-phosphate | phosphatidylinositol 3-kinase VPS34 | Saccharomyces cerevisiae S288C |
| 3 | Although Vps34p-mediated synthesis of PtdIns(3)P is required for the proper sorting of hydrolases from the Golgi to the vacuole, the production of PtdIns(3,5)P2 by Fab1p does not directly affect Golgi to vacuole trafficking, suggesting that PtdIns(3,5)P2 has a distinct function. | phosphatidylinositol 3-phosphate | phosphatidylinositol 3-kinase VPS34 | Saccharomyces cerevisiae S288C |