Pub. Date : 1998 Aug
PMID : 9761458
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mouse interleukin-6 stimulates the HPA axis and increases brain tryptophan and serotonin metabolism. | Tryptophan | interleukin 6 | Mus musculus |
| 2 | However, tryptophan concentrations were elevated in most brain regions studied 1-2 h following iv mIL-6, and 2 h following ip mIL-6, significantly later than the peak HPA response. | Tryptophan | interleukin 6 | Mus musculus |
| 3 | Intracerebroventricular injection of mIL-6 also elevated tryptophan and 5-HIAA in the hypothalamus and brain stem. | Tryptophan | interleukin 6 | Mus musculus |
| 4 | It is possible that the increases of tryptophan and serotonin metabolism may contribute to some of the biological effects of IL-6. | Tryptophan | interleukin 6 | Mus musculus |