Title : VIP and PACAP potentiate the action of glutamate on BDNF expression in mouse cortical neurones.

Pub. Date : 1998 Jan

PMID : 9753136






2 Functional Relationships(s)
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1 In primary cultures of cortical neurones, induction of BDNF mRNA by VIP and PACAP is completely inhibited by the N-methyl-D-aspartate (NMDA) receptor antagonists MK-801 and AP5, therefore indicating that VIP and PACAP do not stimulate BDNF expression directly but rather by potentiating the effect of glutamate tonically released by neurones and acting at NMDA receptors. Dizocilpine Maleate adenylate cyclase activating polypeptide 1 Mus musculus
2 In primary cultures of cortical neurones, induction of BDNF mRNA by VIP and PACAP is completely inhibited by the N-methyl-D-aspartate (NMDA) receptor antagonists MK-801 and AP5, therefore indicating that VIP and PACAP do not stimulate BDNF expression directly but rather by potentiating the effect of glutamate tonically released by neurones and acting at NMDA receptors. Dizocilpine Maleate adenylate cyclase activating polypeptide 1 Mus musculus