Title : Kinetic analysis in living cells of the inhibition of the P-glycoprotein-mediated efflux of anthracyclines by vinca alkaloids.

Pub. Date : 1998 Jul 3

PMID : 9744556






1 Functional Relationships(s)
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1 At pH 7.2, 50% of the P-glycoprotein-mediated efflux of daunorubicin and idarubicin was inhibited by about 40 +/- 10 microM vinblastine and that of pirarubicin by 10 +/- 2 microM vinblastine. Daunorubicin ATP binding cassette subfamily B member 1 Homo sapiens