Title : Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype.

Pub. Date : 1998 Aug

PMID : 9744534






2 Functional Relationships(s)
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1 The relationships in human placenta between DNA damage, CYP1A1 activity and genotype have not been well characterized and may be relevant to risks from transplacental PAH exposure. p-Aminohippuric Acid cytochrome P450 family 1 subfamily A member 1 Homo sapiens
2 Placental PAH-DNA adduct levels were significantly higher in infants with the CYP1A1 MspI restriction site compared with infants without the restriction site (P < 0.01), implicating a genetic factor in inter-individual variation in DNA damage in human placenta. p-Aminohippuric Acid cytochrome P450 family 1 subfamily A member 1 Homo sapiens