Title : Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors.

Pub. Date : 1998 Sep

PMID : 9743293






1 Functional Relationships(s)
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1 Thus, although p53-dependent apoptosis is induced by camptothecin, topotecan and SN-38 in this human ovarian carcinoma cell line, these drugs induce p53-independent death, as measured by clonogenic assay. Topotecan tumor protein p53 Homo sapiens