Pub. Date : 1998 Sep 10
PMID : 9740801
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. | ammonium ferrous sulfate | caspase 8 | Homo sapiens |
| 2 | Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade. | ammonium ferrous sulfate | caspase 8 | Homo sapiens |
| 3 | RESULTS: In a genetic screen for essential components of the Fas-mediated apoptotic cascade, we isolated a Jurkat T lymphocyte cell line deficient in caspase-8 that was completely resistant to Fas-induced apoptosis. | ammonium ferrous sulfate | caspase 8 | Homo sapiens |
| 4 | RESULTS: In a genetic screen for essential components of the Fas-mediated apoptotic cascade, we isolated a Jurkat T lymphocyte cell line deficient in caspase-8 that was completely resistant to Fas-induced apoptosis. | ammonium ferrous sulfate | caspase 8 | Homo sapiens |
| 5 | Fas activation of multiple caspases and of the stress kinase p38 and c-Jun NH2-terminal kinase (JNK) was completely blocked in the caspase-8-deficient cell line. | ammonium ferrous sulfate | caspase 8 | Homo sapiens |
| 6 | Fas activation of multiple caspases and of the stress kinase p38 and c-Jun NH2-terminal kinase (JNK) was completely blocked in the caspase-8-deficient cell line. | ammonium ferrous sulfate | caspase 8 | Homo sapiens |
| 7 | CONCLUSIONS: This study provides the first genetic evidence that caspase-8 occupies an essential and apical position in the Fas signaling pathway and suggests that caspase-8 may participate broadly in multiple apoptotic pathways. | ammonium ferrous sulfate | caspase 8 | Homo sapiens |
| 8 | CONCLUSIONS: This study provides the first genetic evidence that caspase-8 occupies an essential and apical position in the Fas signaling pathway and suggests that caspase-8 may participate broadly in multiple apoptotic pathways. | ammonium ferrous sulfate | caspase 8 | Homo sapiens |