Pub. Date : 1998 Jul-Aug
PMID : 9737824
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clinical pharmacology of rivastigmine: a new-generation acetylcholinesterase inhibitor for the treatment of Alzheimer"s disease. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Rivastigmine (ENA 713, or carbamoylatine) is an acetylcholinesterase (AChE) inhibitor with brain-region selectivity and a long duration of action. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | Rivastigmine (ENA 713, or carbamoylatine) is an acetylcholinesterase (AChE) inhibitor with brain-region selectivity and a long duration of action. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Rivastigmine (ENA 713, or carbamoylatine) is an acetylcholinesterase (AChE) inhibitor with brain-region selectivity and a long duration of action. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | Rivastigmine (ENA 713, or carbamoylatine) is an acetylcholinesterase (AChE) inhibitor with brain-region selectivity and a long duration of action. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | Both preclinical studies and studies in human volunteers have shown that rivastigmine induces substantially greater inhibition of AChE in the central nervous system (CNS) compartment than in the periphery (40% inhibition of central AChE compared with 10% inhibition of plasma butylcholinesterase in healthy volunteers). | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 7 | Both preclinical studies and studies in human volunteers have shown that rivastigmine induces substantially greater inhibition of AChE in the central nervous system (CNS) compartment than in the periphery (40% inhibition of central AChE compared with 10% inhibition of plasma butylcholinesterase in healthy volunteers). | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 8 | Moreover, rivastigmine preferentially inhibits the G1 enzymatic form of AChE, which predominates in the brains of patients with Alzheimer"s disease (AD). | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 9 | Evidence from animal studies also suggests that rivastigmine is a more potent inhibitor of AChE in the cortex and hippocampus, the brain regions most affected by AD. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 10 | The principal metabolite of rivastigmine has at least 10-fold lower activity against AChE compared with the parent drug. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 11 | Distribution of rivastigmine into the CNS is extensive, and inhibition of AChE in the cerebrospinal fluid is detectable 1.2 hours after oral dosing in both healthy volunteers and patients with AD. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 12 | Rivastigmine is inactivated during the process of interacting with and inhibiting AChE, and, in contrast to other AChE inhibitors, the hepatic cytochrome P-450 (CYP-450) system is not involved in the metabolism of rivastigmine. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |