Pub. Date : 1998 Sep
PMID : 9734662
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of RA + DEX were also least able to be overcome by exogenous IL-6. | Radium | interleukin 6 | Homo sapiens |
| 2 | Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. | Radium | interleukin 6 | Homo sapiens |
| 3 | Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. | Radium | interleukin 6 | Homo sapiens |
| 4 | Since RPMI 8226 cells have undetectable IL-6, we investigated U266B1 cells and found that RA and DEX decreased both IL-6 secretion and IL-6 RNA levels. | Radium | interleukin 6 | Homo sapiens |
| 5 | Mechanistically, IL-6R down-regulation by RA was enhanced by DEX, whereas IL-6 protein and RNA levels were reduced by DEX and by RA. | Radium | interleukin 6 | Homo sapiens |
| 6 | In summary, combinations of RA + DEX were not only more effective in inhibiting myeloma cells growth by the dual mechanisms of decreasing proliferative fraction and increasing apoptotic fraction, but were also less able to be overcome by IL-6. | Radium | interleukin 6 | Homo sapiens |