Title : Potentiation of CD95L-induced apoptosis of human malignant glioma cells by topotecan involves inhibition of RNA synthesis but not changes in CD95 or CD95L protein expression.

Pub. Date : 1998 Sep

PMID : 9732400






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Prolonged exposure for 72 hr to high nanomolar to low micromolar concentrations of topotecan augmented p21 protein levels and induced G2/M arrest but failed to consistently alter BCL-2 and BAX protein levels, did not induce significant DNA/topoisomerase I complex formation and did not inhibit RNA synthesis. Topotecan H3 histone pseudogene 16 Homo sapiens