Title : Molecular mechanisms of photoaging and its prevention by retinoic acid: ultraviolet irradiation induces MAP kinase signal transduction cascades that induce Ap-1-regulated matrix metalloproteinases that degrade human skin in vivo.

Pub. Date : 1998 Aug

PMID : 9732061






1 Functional Relationships(s)
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1 All-trans retinoic acid acts to inhibit induction of c-Jun protein by ultraviolet irradiation, thereby preventing increased matrix metalloproteinases and ensuing dermal damage. Tretinoin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens