Title : Prostaglandin F2alpha stimulates CFTR activity by PKA- and PKC-dependent phosphorylation.

Pub. Date : 1998 Sep

PMID : 9730948






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 As measured by I- efflux, maximal CFTR activity with PGF and FSK was equivalent and fivefold greater than that with PMA. Colforsin cystic fibrosis transmembrane conductance regulator Mus musculus
2 Both PGF and PMA had additive effects on FSK-dependent CFTR activity. Colforsin cystic fibrosis transmembrane conductance regulator Mus musculus
3 PMA did not increase cellular cAMP, and maximal PGF-dependent CFTR activity occurred with approximately 20% of the cellular cAMP observed with FSK-dependent activation. Colforsin cystic fibrosis transmembrane conductance regulator Mus musculus
4 As judged by protease digestion, the sites of in vivo CFTR phosphorylation with FSK and PMA differed. Colforsin cystic fibrosis transmembrane conductance regulator Mus musculus