Pub. Date : 1998 Sep
PMID : 9722676
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium chloride. | Hemin | heme oxygenase 1 | Homo sapiens |
| 2 | The effect of a tyrosine kinase inhibitor, herbimycin A, on the induction of heme oxygenase-1 (HO-1) mRNA in HeLa cells upon exposure to hemin, sodium arsenite and cadmium chloride was examined. | Hemin | heme oxygenase 1 | Homo sapiens |
| 3 | The effect of a tyrosine kinase inhibitor, herbimycin A, on the induction of heme oxygenase-1 (HO-1) mRNA in HeLa cells upon exposure to hemin, sodium arsenite and cadmium chloride was examined. | Hemin | heme oxygenase 1 | Homo sapiens |
| 4 | The induction of HO-1 mRNA by hemin was inhibited when the cells were pretreated with herbimycin A. | Hemin | heme oxygenase 1 | Homo sapiens |
| 5 | Genistein (50 microM), another tyrosine kinase inhibitor, also inhibited the induction of HO-1 mRNA by hemin, arsenite, and cadmium. | Hemin | heme oxygenase 1 | Homo sapiens |
| 6 | Nuclear runoff assays revealed that herbimycin blocked the hemin-induced transcription of the HO-1 gene. | Hemin | heme oxygenase 1 | Homo sapiens |
| 7 | When HeLa cells were treated with a specific inhibitor of the mitogen-activated protein kinase (MAPK)/extracellular-signal regulated kinase cascade, PD58059 (100 microM), suppression of the cadmium-dependent HO-1 induction was not observed, but the hemin- or arsenite-dependent induction was slightly inhibited. | Hemin | heme oxygenase 1 | Homo sapiens |