Pub. Date : 1998 Aug
PMID : 9715793
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of losartan and captopril on endothelin-1 production in blood vessels and glomeruli of rats with reduced renal mass. | Losartan | endothelin 1 | Rattus norvegicus |
| 2 | Treatment of uremic rats with losartan or captopril reduced irET-1 concentration in the thoracic aorta and preglomerular arteries (P < .05), but ir-ET-1 concentration in the mesenteric arterial bed was unchanged. | Losartan | endothelin 1 | Rattus norvegicus |
| 3 | Although both drugs completely prevented the increase in proteinuria, losartan but not captopril significantly reduced ir-ET-1 concentration in glomeruli (P < .05) and normalized urinary ir-ET-1 excretion. | Losartan | endothelin 1 | Rattus norvegicus |
| 4 | Although both drugs completely prevented the increase in proteinuria, losartan but not captopril significantly reduced ir-ET-1 concentration in glomeruli (P < .05) and normalized urinary ir-ET-1 excretion. | Losartan | endothelin 1 | Rattus norvegicus |
| 5 | The beneficial effects of the AT1 antagonist losartan could be attributable to the attenuation of Ang II-induced ET-1 production in this rat remnant kidney model of chronic renal failure, whereas those of the ACE-I captopril are not related to changes in ET-1 production in glomeruli. | Losartan | endothelin 1 | Rattus norvegicus |
| 6 | The beneficial effects of the AT1 antagonist losartan could be attributable to the attenuation of Ang II-induced ET-1 production in this rat remnant kidney model of chronic renal failure, whereas those of the ACE-I captopril are not related to changes in ET-1 production in glomeruli. | Losartan | endothelin 1 | Rattus norvegicus |