Title : Repair kinetics of abasic sites in mammalian cells selectively monitored by the aldehyde reactive probe (ARP).

Pub. Date : 1998 Jan-Mar

PMID : 9708359






2 Functional Relationships(s)
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1 The amount of AP sites in MMS-treated HeLa cells transiently increased at 3 h, then gradually decreased to 40% at 24 h. The presence of adenine, an inhibitor of AP endonucleases, in the repair incubation of MMS-treated cells induced moderate accumulation of AP sites, suggesting inhibition of the activities of MPG as well as AP endonucleases by adenine metabolites. Methyl Methanesulfonate N-methylpurine DNA glycosylase Homo sapiens
2 The amount of AP sites in MMS-treated HeLa cells transiently increased at 3 h, then gradually decreased to 40% at 24 h. The presence of adenine, an inhibitor of AP endonucleases, in the repair incubation of MMS-treated cells induced moderate accumulation of AP sites, suggesting inhibition of the activities of MPG as well as AP endonucleases by adenine metabolites. Methyl Methanesulfonate N-methylpurine DNA glycosylase Homo sapiens