Pub. Date : 1998 Aug
PMID : 9703277
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 2-Chlorpromazine (10 microM) completely inhibited ATP-dependent P-glycoprotein-mediated vinblastine accumulation in the vesicles. | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The results were consistent with a two-state concerted model in which P-glycoprotein exists in two conformational states, P(A) and P(B), where 2-chlorpromazine is transported by the conformer, P(A), and vinblastine by the conformer, P(B). | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | We propose a minimal kinetic model whereby in these preloaded vesicles the complex VV.P(A).CC is formed, where two internal binding sites of P-glycoprotein (P(A)) are occupied by vinblastine (V) and the two external sites are occupied by 2-chlorpromazine (C). | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | When the two binding sites on both the inside and outside of P-glycoprotein are saturated with ligands vinblastine is effluxed at a very rapid rate, and vice versa when vesicles are preloaded with 2-chlorpromazine and vinblastine is added outside. | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | When the two binding sites on both the inside and outside of P-glycoprotein are saturated with ligands vinblastine is effluxed at a very rapid rate, and vice versa when vesicles are preloaded with 2-chlorpromazine and vinblastine is added outside. | Vinblastine | ATP binding cassette subfamily B member 1 | Homo sapiens |