Pub. Date : 1998 Aug
PMID : 9694927
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both compounds use the same cytochrome-P450 metabolic pathway, resulting in an increase in plasma concentration of terfenadine. | Terfenadine | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | These potential dual actions on HERG currents suggest that precautions should be taken in long-term ketoconazole treatment, particularly for patients who have decreased liver function or are on a drug regimen requiring simultaneous medications that use cytochrome-P450 for breakdown, such as terfenadine or erythromycin, or Class III antiarrhythmic drugs. | Terfenadine | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |