Title : Etoposide and cisplatin induced apoptosis in activated RAW 264.7 macrophages is attenuated by cAMP-induced gene expression.

Pub. Date : 1998 Jul 23

PMID : 9690520






1 Functional Relationships(s)
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1 Here we report that exposure of macrophages to lipopolysaccharide/interferon-gamma or lipophilic cAMP analogs such as dibutyryl-cAMP or 8-bromo-cAMP for 15 h attenuated DNA fragmentation and accumulation of the tumor suppressor p53 in response to the chemotherapeutic agents cisplatin and etoposide, compared to cells that received chemotherapeutic agents only. 8-Bromo Cyclic Adenosine Monophosphate tumor protein p53 Homo sapiens