Pub. Date : 1998 Aug 4
PMID : 9689061
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 2 | The mechanism of superoxide generation by endothelial nitric oxide synthase (eNOS) was investigated by the electron spin resonance spin-trapping technique using 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 3 | The mechanism of superoxide generation by endothelial nitric oxide synthase (eNOS) was investigated by the electron spin resonance spin-trapping technique using 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 4 | In the absence of calcium/calmodulin, eNOS produces low amounts of superoxide. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 5 | Upon activating eNOS electron transfer reactions by calcium/calmodulin binding, superoxide formation is increased. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 6 | However, the concomitant addition of L-arginine and tetrahydrobiopterin (BH4) abolishes superoxide generation by eNOS. | Superoxides | nitric oxide synthase 3 | Homo sapiens |
| 7 | Our data indicate that modulation of BH4 concentration may regulate the ratio of superoxide to nitric oxide generated by eNOS. | Superoxides | nitric oxide synthase 3 | Homo sapiens |