Pub. Date : 1998 May
PMID : 9681667
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acetylcholinesterase activity in red blood cells was assayed 24 h after drug administration as a biological marker of eptastigmine plasma concentrations. | physostigmine heptyl | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | RESULTS: Mean maximum acetylcholinesterase inhibition (Imax) was 39.9% after eptastigmine without food and 33.1% after eptastigmine with food. | physostigmine heptyl | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | RESULTS: Mean maximum acetylcholinesterase inhibition (Imax) was 39.9% after eptastigmine without food and 33.1% after eptastigmine with food. | physostigmine heptyl | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | Areas under the curve of acetylcholinesterase per cent inhibition from 0 to 8 h after drug administration (AUC0-8) were 198% h after eptastigmine without food and 124% h after eptastigmine with food. | physostigmine heptyl | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | Areas under the curve of acetylcholinesterase per cent inhibition from 0 to 8 h after drug administration (AUC0-8) were 198% h after eptastigmine without food and 124% h after eptastigmine with food. | physostigmine heptyl | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | CONCLUSIONS: The ingestion of food significantly reduces the bioavailability of eptastigmine estimated by the assay of red blood cell acetylcholinesterase activity. | physostigmine heptyl | acetylcholinesterase (Cartwright blood group) | Homo sapiens |