Pub. Date : 1998 May
PMID : 9681662
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Catechol-O-methyltransferase: variation in enzyme activity and inhibition by entacapone and tolcapone. | entacapone | catechol-O-methyltransferase | Homo sapiens |
| 2 | OBJECTIVE: The aim of this investigation was to study the variation of catechol-O-methyltransferase (COMT) activity in the human liver, duodenal mucosa and renal cortex, and to investigate the inhibition of COMT by entacapone and tolcapone. | entacapone | catechol-O-methyltransferase | Homo sapiens |
| 3 | OBJECTIVE: The aim of this investigation was to study the variation of catechol-O-methyltransferase (COMT) activity in the human liver, duodenal mucosa and renal cortex, and to investigate the inhibition of COMT by entacapone and tolcapone. | entacapone | catechol-O-methyltransferase | Homo sapiens |
| 4 | CONCLUSION: Entacapone and tolcapone were powerful inhibitors of COMT and their IC50 estimates were 151 and 773 nM (P = 0.008), respectively, in the liver; consistent results were obtained with the other tissues. | entacapone | catechol-O-methyltransferase | Homo sapiens |