Title : Retinoic acid induced mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase-dependent MAP kinase activation needed to elicit HL-60 cell differentiation and growth arrest.

Pub. Date : 1998 Jul 15

PMID : 9679985






3 Functional Relationships(s)
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Protein Name
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1 ERK2 activation by mitogen-activated protein/ERK kinase (MEK) was necessary for RA-induced differentiation in studies using PD98059 to block MEK phosphorylation. Tretinoin mitogen-activated protein kinase kinase 7 Homo sapiens
2 ERK2 activation by mitogen-activated protein/ERK kinase (MEK) was necessary for RA-induced differentiation in studies using PD98059 to block MEK phosphorylation. Tretinoin mitogen-activated protein kinase kinase 7 Homo sapiens
3 The results thus show that RA augments MEK-dependent ERK2 activation that is needed for subsequent RB hypophosphorylation, cell differentiation, and G0 arrest. Tretinoin mitogen-activated protein kinase kinase 7 Homo sapiens