Title : Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: the critical role of polyglutamylation.

Pub. Date : 1998 Jul 15

PMID : 9679969






1 Functional Relationships(s)
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1 A hypothesis to explain this general phenomenon involves the critical role of folylpoly-gamma-glutamate synthetase and the effect of the DHFR inhibitor in decreasing the protection by folic acid of cells to the other antifolates. Folic Acid folylpolyglutamate synthase Homo sapiens