Pub. Date : 1998 Aug 1
PMID : 9677316
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Maximal activation occurred at 15-30 min, but was still detectable after 2 h. Both ERK1 and ERK2 were activated 16-fold by 0.1 mM H2O2 with a similar time course to the SAPKs/JNKs, and this was comparable with their activation by 1 microM PMA, the most powerful activator of ERKs that we have so far identified in these cells. | Hydrogen Peroxide | mitogen activated protein kinase 3 | Rattus norvegicus |
2 | Maximal activation occurred at 15-30 min, but was still detectable after 2 h. Both ERK1 and ERK2 were activated 16-fold by 0.1 mM H2O2 with a similar time course to the SAPKs/JNKs, and this was comparable with their activation by 1 microM PMA, the most powerful activator of ERKs that we have so far identified in these cells. | Hydrogen Peroxide | mitogen activated protein kinase 3 | Rattus norvegicus |
3 | The activation of ERKs by H2O2 was inhibited by PD98059, which inhibits the activation of MAPK (or ERK) kinases, and by the protein kinase C (PKC) inhibitor, GF109203X. | Hydrogen Peroxide | mitogen activated protein kinase 3 | Rattus norvegicus |