Pub. Date : 1998 Jul
PMID : 9676763
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reduced priming effect of interleukin 3 on IgE mediated basophil histamine release in patients with systemic sclerosis. | Histamine | interleukin 3 | Homo sapiens |
| 2 | OBJECTIVE: To determine the capacity of interleukin 3 (IL-3) to induce and enhance basophil histamine release in patients with systemic sclerosis (SSc). | Histamine | interleukin 3 | Homo sapiens |
| 3 | The priming effect of IL-3 on anti-IgE and fMLP induced histamine release was evaluated. | Histamine | interleukin 3 | Homo sapiens |
| 4 | IL-3 was a weak basophil agonist in both populations, since net histamine release did not exceed 10% of total histamine content in any case. | Histamine | interleukin 3 | Homo sapiens |
| 5 | IL-3 was a weak basophil agonist in both populations, since net histamine release did not exceed 10% of total histamine content in any case. | Histamine | interleukin 3 | Homo sapiens |
| 6 | IL-3 enhanced anti-IgE and fMLP induced histamine release in a dose dependent fashion. | Histamine | interleukin 3 | Homo sapiens |
| 7 | However, the enhancement of anti-IgE induced histamine release by IL-3 was significantly lower in patients with SSc than in controls (p < 0.01 at 0.1 ng/ml IL-3; p < 0.05 at 1 and 10 ng/ml IL-3). | Histamine | interleukin 3 | Homo sapiens |
| 8 | However, the enhancement of anti-IgE induced histamine release by IL-3 was significantly lower in patients with SSc than in controls (p < 0.01 at 0.1 ng/ml IL-3; p < 0.05 at 1 and 10 ng/ml IL-3). | Histamine | interleukin 3 | Homo sapiens |
| 9 | However, the enhancement of anti-IgE induced histamine release by IL-3 was significantly lower in patients with SSc than in controls (p < 0.01 at 0.1 ng/ml IL-3; p < 0.05 at 1 and 10 ng/ml IL-3). | Histamine | interleukin 3 | Homo sapiens |
| 10 | CONCLUSION: Basophil response to anti-IgE and the priming effect of IL-3 on IgE mediated basophil histamine release are lower in patients with SSc than in controls. | Histamine | interleukin 3 | Homo sapiens |