Title : Aldehyde reductase: the role of C-terminal residues in defining substrate and cofactor specificities.

Pub. Date : 1998 Jul 15

PMID : 9675019






1 Functional Relationships(s)
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1 The only major structural difference between aldehyde reductase, a primarily NADPH-dependent aldo-keto reductase, and aldose reductase, a dually coenzyme-specific (NADPH/NADH) member of the same superfamily, is an additional eight amino acid residues in the substrate/inhibitor binding site (C-terminal region) of aldehyde reductase. NADP aldo-keto reductase family 1 member A1 Homo sapiens