Pub. Date : 1998 Jul 15
PMID : 9675018
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In primary cultures of human hepatocytes, paclitaxel (Taxol), at pharmacological concentrations, was demonstrated to induce immunoreactive cytochrome P4503A (CYP3A). | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | In primary cultures of human hepatocytes, paclitaxel (Taxol), at pharmacological concentrations, was demonstrated to induce immunoreactive cytochrome P4503A (CYP3A). | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | In primary cultures of human hepatocytes, paclitaxel (Taxol), at pharmacological concentrations, was demonstrated to induce immunoreactive cytochrome P4503A (CYP3A). | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | In primary cultures of human hepatocytes, paclitaxel (Taxol), at pharmacological concentrations, was demonstrated to induce immunoreactive cytochrome P4503A (CYP3A). | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | In general, exposure to increasing concentrations of Taxol (0.2 to 10 microM) resulted in increases in immunoreactive CYP3A. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 7 | In four of the cultures, treatment of hepatocytes with the lowest concentration of Taxol tested (0.2 microM) resulted in approximately two-fold increases in CYP3A. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 8 | Taxol was almost as effective as rifampicin in inducing CYP3A in two of the cultures, but less effective than rifampicin in two other cultures. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 9 | CYP3A4 mRNA was increased by Taxol. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 10 | These results demonstrate that Taxol is a potent inducer of CYP3A in human hepatocytes. | Paclitaxel | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |