Title : Inhibition of CD28/CD3-mediated costimulation of naive and memory human T lymphocytes by intracellular incorporation of polyclonal antibodies specific for the activator protein-1 transcriptional complex.

Pub. Date : 1998 Jul 15

PMID : 9670939






1 Functional Relationships(s)
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1 The intracellular incorporation of Abs specific for c-Fos and c-Jun family members by scrape loading inhibited the production and intracellular accumulation of IL-2 within 6 h of costimulation with PMA/ionomycin, or costimulation by CD28 and CD3 ligation. Ionomycin Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens