Title : Molecular modeling studies on binding of bFGF to heparin and its receptor FGFR1.

Pub. Date : 1998 Jun

PMID : 9669548






1 Functional Relationships(s)
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1 In the proposed model heparin bridges the two bFGF monomers in a specific orientation and the resulting complex induces FGF receptor dimerization, suggesting that in the oligosaccharide induced recognition process sugars orient the molecules in a way that brings about specific protein-protein or protein-carbohydrate interactions. Oligosaccharides fibroblast growth factor 2 Homo sapiens