Title : Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type-specific activation of mitogen-activated protein kinases.

Pub. Date : 1998 Jul 24

PMID : 9668117






4 Functional Relationships(s)
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1 Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Arachidonic Acid mitogen-activated protein kinase 14 Homo sapiens
2 We now report that arachidonic acid stimulated the appearance of dual-phosphorylated (active) p38 mitogen-activated protein kinase as detected by Western blotting in HeLa cells, HL60 cells, human neutrophils, and human umbilical vein endothelial cells but not Jurkat cells. Arachidonic Acid mitogen-activated protein kinase 14 Homo sapiens
3 An increase in p38 kinase activity caused by arachidonic acid was also observed. Arachidonic Acid mitogen-activated protein kinase 14 Homo sapiens
4 Further studies with neutrophils show that the stimulation of p38 dual phosphorylation by arachidonic acid was transient, peaking at 5 min, and was concentration-dependent. Arachidonic Acid mitogen-activated protein kinase 14 Homo sapiens