Title : Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones.

Pub. Date : 1998 Jun

PMID : 9667077






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 6 beta-Hydroxylation of progesterone was catalysed most efficiently by CYP3A4, followed by CYP2D6. Progesterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 CYP3A4 showed the highest progesterone 16 alpha-hydroxylation activity, followed by CYP1A1 and CYP2D6. Progesterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 Addition of nifedipine, a typical substrate of CYP3A4, inhibited the 6 beta- and 16 alpha-hydroxylation of progesterone by CYP3A4. Progesterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens
4 Addition of nifedipine, a typical substrate of CYP3A4, inhibited the 6 beta- and 16 alpha-hydroxylation of progesterone by CYP3A4. Progesterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens