Title : Immune-endocrine interactions in the mammalian adrenal gland: facts and hypotheses.

Pub. Date : 1998

PMID : 9666567






1 Functional Relationships(s)
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1 IL-2, IL-3, IL-6, and INF-alpha are able to directly stimulate glucocorticoid production by zona fasciculata and zona reticularis cells, whereas IL-1 exerts an analogous effect through an indirect mechanism involving the stimulation of catecholamine release by chromaffin cells and/or the activation of the intramedullary CRH/ACTH system; again, TNF-alpha depresses glucocorticoid synthesis. Catecholamines interleukin 6 Homo sapiens