Title : Catecholamines and lipopolysaccharide synergistically induce the release of interleukin-6 from thymic epithelial cells.

Pub. Date : 1998 Jun 15

PMID : 9663564






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1 Catecholamines and lipopolysaccharide synergistically induce the release of interleukin-6 from thymic epithelial cells. Catecholamines interleukin 6 Rattus norvegicus
2 We investigated the influence of catecholamines on the synthesis of interleukin-1 (IL-1) and IL-6 by cultured rat thymic epithelial cells. Catecholamines interleukin 6 Rattus norvegicus
3 Release of IL-6 was stimulated only scarcely by catecholamines or tumor necrosis factor-alpha (TNF-alpha) and moderately by LPS alone. Catecholamines interleukin 6 Rattus norvegicus
4 After co-stimulation IL-6 mRNA was first detected after 3-4 h and a constant increase of IL-6 bioactivity in the culture supernatant was measured for up to 48 h. Since IL-6 is an important factor for thymocyte differentiation and proliferation, the findings demonstrate an influence of neuronal or hormonal catecholamines on the thymic microenvironment that is created by thymic epithelial cells. Catecholamines interleukin 6 Rattus norvegicus
5 After co-stimulation IL-6 mRNA was first detected after 3-4 h and a constant increase of IL-6 bioactivity in the culture supernatant was measured for up to 48 h. Since IL-6 is an important factor for thymocyte differentiation and proliferation, the findings demonstrate an influence of neuronal or hormonal catecholamines on the thymic microenvironment that is created by thymic epithelial cells. Catecholamines interleukin 6 Rattus norvegicus
6 After co-stimulation IL-6 mRNA was first detected after 3-4 h and a constant increase of IL-6 bioactivity in the culture supernatant was measured for up to 48 h. Since IL-6 is an important factor for thymocyte differentiation and proliferation, the findings demonstrate an influence of neuronal or hormonal catecholamines on the thymic microenvironment that is created by thymic epithelial cells. Catecholamines interleukin 6 Rattus norvegicus