Title : Cytotoxicity and apoptosis produced by arachidonic acid in HepG2 cells overexpressing human cytochrome P-4502E1.

Pub. Date : 1998 Jun

PMID : 9660301






1 Functional Relationships(s)
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1 It is proposed that elevated production of reactive oxygen intermediates by cells expressing CYP2E1 can cause lipid peroxidation, which subsequently promotes apoptosis and cell toxicity when the cells are enriched with polyunsaturated fatty acids such as arachidonic acid. Fatty Acids, Unsaturated cytochrome P450 family 2 subfamily E member 1 Homo sapiens