Title : Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines.

Pub. Date : 1998 Jul

PMID : 9658196






1 Functional Relationships(s)
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1 In the current study, the potential blocking ability of K+ channels encoded by the human ether-a-go-go related gene (HERG) by the piperazine H1 receptor antagonist cetirizine has been examined and compared with that of other second-generation antihistamines (astemizole, terfenadine, and loratadine). Loratadine potassium voltage-gated channel subfamily H member 2 Homo sapiens