Pub. Date : 1998 Jul 15
PMID : 9657968
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | This H2O2-induced apoptosis was markedly enhanced when ERK2 activation was selectively inhibited by PD098059. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | Because NF-kappaB activation by H2O2 is potentially related to both the ERK and JNK/SAPK signalling pathways, we examined the effects of inhibiting the activation of NF-kappaB; this interference had no effect on the cellular response to H2O2. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | Bcl-2 acts independently and downstream of ERK and JNK/SAPK to enhance the survival of H2O2-treated cells. | Hydrogen Peroxide | mitogen-activated protein kinase 1 | Homo sapiens |