Title : The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival.

Pub. Date : 1998 Jul 15

PMID : 9657968






7 Functional Relationships(s)
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1 Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. Hydrogen Peroxide mitogen-activated protein kinase 1 Homo sapiens
2 Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. Hydrogen Peroxide mitogen-activated protein kinase 1 Homo sapiens
3 Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. Hydrogen Peroxide mitogen-activated protein kinase 1 Homo sapiens
4 Treatment of HeLa cells with H2O2 resulted in a time- and dose-dependent induction of apoptosis accompanied by sustained activation of all three MAPK subfamilies: extracellular signal-regulated protein kinase (ERK), c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38. Hydrogen Peroxide mitogen-activated protein kinase 1 Homo sapiens
5 This H2O2-induced apoptosis was markedly enhanced when ERK2 activation was selectively inhibited by PD098059. Hydrogen Peroxide mitogen-activated protein kinase 1 Homo sapiens
6 Because NF-kappaB activation by H2O2 is potentially related to both the ERK and JNK/SAPK signalling pathways, we examined the effects of inhibiting the activation of NF-kappaB; this interference had no effect on the cellular response to H2O2. Hydrogen Peroxide mitogen-activated protein kinase 1 Homo sapiens
7 Bcl-2 acts independently and downstream of ERK and JNK/SAPK to enhance the survival of H2O2-treated cells. Hydrogen Peroxide mitogen-activated protein kinase 1 Homo sapiens