Pub. Date : 1998 May
PMID : 9657254
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: The aim of this study was to examine the role of histamine in regulation of IL-6 and M-CSF gene expression in bone marrow stromal cells. | Histamine | colony stimulating factor 1 (macrophage) | Mus musculus |
| 2 | RESULTS: Histamine caused a distinct accumulation of IL-6 mRNA in the cells, whereas it decreased M-CSF transcripts. | Histamine | colony stimulating factor 1 (macrophage) | Mus musculus |
| 3 | CONCLUSIONS: These results, together with the results of our previous studies, suggest that histamine produced by stromal macrophages differentially regulates the production of IL-6 and M-CSF in other kinds of stromal cells and hence promotes differentiation and/or proliferation of hematopoietic progenitor cells. | Histamine | colony stimulating factor 1 (macrophage) | Mus musculus |