Pub. Date : 1998 May
PMID : 9656574
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Theophylline reduces serum levels of ECP in vitro]. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 2 | Measurement of serum levels of ECP has been widely used for monitoring airway inflammation in bronchial asthma and recently been applied to measure anti-inflammatory effect of theophylline. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 3 | However, reduced levels of ECP in theophylline-administered patients may express not only in vivo effect of theophylline but also in vitro effect after sampling because serum ECP measures released ECP during coagulation and theophylline has been reported to inhibit eosinophil degranulation in vitro. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 4 | However, reduced levels of ECP in theophylline-administered patients may express not only in vivo effect of theophylline but also in vitro effect after sampling because serum ECP measures released ECP during coagulation and theophylline has been reported to inhibit eosinophil degranulation in vitro. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 5 | However, reduced levels of ECP in theophylline-administered patients may express not only in vivo effect of theophylline but also in vitro effect after sampling because serum ECP measures released ECP during coagulation and theophylline has been reported to inhibit eosinophil degranulation in vitro. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 6 | However, reduced levels of ECP in theophylline-administered patients may express not only in vivo effect of theophylline but also in vitro effect after sampling because serum ECP measures released ECP during coagulation and theophylline has been reported to inhibit eosinophil degranulation in vitro. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 7 | However, reduced levels of ECP in theophylline-administered patients may express not only in vivo effect of theophylline but also in vitro effect after sampling because serum ECP measures released ECP during coagulation and theophylline has been reported to inhibit eosinophil degranulation in vitro. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 8 | In order to answer the question, we tested whether theophylline added to blood after sampling reduces measured levels of serum ECP. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 9 | Theophylline significantly reduced serum ECP in a concentration-dependent manner. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 10 | Percent reduction of ECP levels at 1 hour of incubation were 11.9%, 18.7%, 22.8%, and 51.7% at theophylline levels of 5, 12.5, 22.5, and 120 micrograms/ml, respectively. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 11 | Kinetics of serum ECP release was also inhibited in the presence of theophylline. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 12 | These results suggest that in vitro effect of theophylline on serum ECP levels should be considered when data of serum ECP in patients who take theophylline are interpreted. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 13 | These results suggest that in vitro effect of theophylline on serum ECP levels should be considered when data of serum ECP in patients who take theophylline are interpreted. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 14 | These results suggest that in vitro effect of theophylline on serum ECP levels should be considered when data of serum ECP in patients who take theophylline are interpreted. | Theophylline | ribonuclease A family member 3 | Homo sapiens |
| 15 | These results suggest that in vitro effect of theophylline on serum ECP levels should be considered when data of serum ECP in patients who take theophylline are interpreted. | Theophylline | ribonuclease A family member 3 | Homo sapiens |