Title : CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription.

Pub. Date : 1998 Jul 10

PMID : 9651391






1 Functional Relationships(s)
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1 We conclude that when cells are incubated in the absence of sterols, the transcriptional activation of the HMG-CoA synthase, HMG-CoA reductase, FPP synthase, and low density lipoprotein receptor genes is dependent on a specific interaction between SREBP, which is bound to the promoter DNA, and the amino-terminal domain (amino acids 1-451) of CBP. Sterols farnesyl diphosphate synthase Homo sapiens