Title : Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing.

Pub. Date : 1998 Jul 10

PMID : 9651388






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing. Nigericin interleukin 1 beta Homo sapiens
2 Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing. Nigericin interleukin 1 beta Homo sapiens
3 Rapid secretion of mature, 17-kDa IL-1beta occurred, in the presence of nigericin (4-16 microM). Nigericin interleukin 1 beta Homo sapiens
4 Addition of the irreversible interleukin-1beta-converting enzyme (ICE) inhibitor, Z-Val-Ala-Asp-dichlorobenzoate, or a radicicol analog, inhibited nigericin-induced mature IL-1beta release and activation of p45 ICE precursor. Nigericin interleukin 1 beta Homo sapiens
5 We have therefore shown conclusively, for the first time, that nigericin-induced release of IL-1beta is dependent upon activation of p45 ICE processing. Nigericin interleukin 1 beta Homo sapiens