Pub. Date : 1998 Jul 10
PMID : 9651388
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing. | Nigericin | interleukin 1 beta | Homo sapiens |
| 2 | Increased mature interleukin-1beta (IL-1beta) secretion from THP-1 cells induced by nigericin is a result of activation of p45 IL-1beta-converting enzyme processing. | Nigericin | interleukin 1 beta | Homo sapiens |
| 3 | Rapid secretion of mature, 17-kDa IL-1beta occurred, in the presence of nigericin (4-16 microM). | Nigericin | interleukin 1 beta | Homo sapiens |
| 4 | Addition of the irreversible interleukin-1beta-converting enzyme (ICE) inhibitor, Z-Val-Ala-Asp-dichlorobenzoate, or a radicicol analog, inhibited nigericin-induced mature IL-1beta release and activation of p45 ICE precursor. | Nigericin | interleukin 1 beta | Homo sapiens |
| 5 | We have therefore shown conclusively, for the first time, that nigericin-induced release of IL-1beta is dependent upon activation of p45 ICE processing. | Nigericin | interleukin 1 beta | Homo sapiens |