Pub. Date : 1998 Jul
PMID : 9649464
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND & AIMS: Selective inhibitors of cyclooxygenase (COX)-2 are being developed as gastrointestinal-sparing anti-inflammatory drugs based on the premise that this isoform is solely responsible for prostaglandin synthesis at sites of inflammation, whereas COX-1 produces prostaglandins important for maintenance of mucosal integrity. | Prostaglandins | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |
| 2 | BACKGROUND & AIMS: Selective inhibitors of cyclooxygenase (COX)-2 are being developed as gastrointestinal-sparing anti-inflammatory drugs based on the premise that this isoform is solely responsible for prostaglandin synthesis at sites of inflammation, whereas COX-1 produces prostaglandins important for maintenance of mucosal integrity. | Prostaglandins | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |
| 3 | The degree of suppression of prostaglandin synthesis at the site of inflammation correlated significantly with inhibition of COX-1 but not COX-2. | Prostaglandins | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |
| 4 | To achieve desirable anti-inflammatory effects, COX-2 inhibitors needed to be given at doses in which selectivity was lost, leading to suppression of gastric prostaglandin synthesis and to mucosal injury. | Prostaglandins | cytochrome c oxidase II, mitochondrial | Rattus norvegicus |