Pub. Date : 1998 Jun 29
PMID : 9648724
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation of p130Cas by angiotensin II is dependent on c-Src, intracellular Ca2+, and protein kinase C. p130Cas is a signaling molecule that was initially found to be tyrosine-phosphorylated in v-Crk and v-Src transformed cells. | Tyrosine | angiotensinogen | Homo sapiens |
| 2 | We characterized the regulation of p130Cas tyrosine phosphorylation in vascular smooth muscle cells by angiotensin II (Ang II). | Tyrosine | angiotensinogen | Homo sapiens |
| 3 | We characterized the regulation of p130Cas tyrosine phosphorylation in vascular smooth muscle cells by angiotensin II (Ang II). | Tyrosine | angiotensinogen | Homo sapiens |
| 4 | The Ang II-induced tyrosine phosphorylation of p130Cas was also dependent on an active Src family tyrosine kinase, since it could be blocked by the Src kinase inhibitors geldanamycin and PP1. | Tyrosine | angiotensinogen | Homo sapiens |
| 5 | Inhibition of protein kinase C by either calphostin C or phorbol 12-myristate 13-acetate downregulation inhibited the Ang II-induced tyrosine phosphorylation of p130Cas. | Tyrosine | angiotensinogen | Homo sapiens |
| 6 | These results are the first to demonstrate that the tyrosine phosphorylation of p130Cas by Ang II is transduced by the Src, intracellular Ca2+, protein kinase C signaling pathway. | Tyrosine | angiotensinogen | Homo sapiens |