Pub. Date : 1998 Jun
PMID : 9647467
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of reactive oxygen species in the signalling cascade of cyclosporine A-mediated up-regulation of eNOS in vascular endothelial cells. | Reactive Oxygen Species | nitric oxide synthase 3 | Bos taurus |
| 2 | As some effects of CsA may be mediated by reactive oxygen species (ROS), present experiments were devoted to test the hypothesis that the CsA-induced eNOS up-regulation could be dependent on an increased synthesis of ROS. | Reactive Oxygen Species | nitric oxide synthase 3 | Bos taurus |
| 3 | Two ROS generating systems, xanthine plus xanthine oxidase (XXO) and glucose oxidase (GO), increased the expression of eNOS mRNA in BAEC, an effect which was maximal after 8 h of incubation (XXO: 168+/-21% of control values. | Reactive Oxygen Species | nitric oxide synthase 3 | Bos taurus |
| 4 | The ROS-dependent increased eNOS mRNA expression was followed by an increase in eNOS activity. | Reactive Oxygen Species | nitric oxide synthase 3 | Bos taurus |
| 5 | The ROS-dependent increased eNOS mRNA expression was followed by an increase in eNOS activity. | Reactive Oxygen Species | nitric oxide synthase 3 | Bos taurus |
| 6 | The present results support a role for ROS, particularly superoxide anion and hydrogen peroxide, as mediators of the CsA-induced eNOS mRNA up-regulation. | Reactive Oxygen Species | nitric oxide synthase 3 | Bos taurus |