Pub. Date : 1998 Aug
PMID : 9644216
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The purpose of this study was to examine how intracellular pH (pHi) regulation and histamine release are affected by HCO3- in rat peritoneal mast cells. | Bicarbonates | glucose-6-phosphate isomerase | Rattus norvegicus |
| 2 | This fall in pHi is inhibited by the carbonic anhydrase inhibitor dichlorphenamide and is Na+-independent, indicating the involvement of Na+-independent Cl-/HCO3- exchange activity. | Bicarbonates | glucose-6-phosphate isomerase | Rattus norvegicus |
| 3 | Histamine release stimulated by antigen and compound 48/80 was substantially reduced in the presence of HEPES/ HCO3- buffer (pHo 7.4, pHi 6.66). | Bicarbonates | glucose-6-phosphate isomerase | Rattus norvegicus |
| 4 | Histamine release was increased, however, when pHi was clamped to 6.66 in HCO3--free media (pHo 6.9). | Bicarbonates | glucose-6-phosphate isomerase | Rattus norvegicus |
| 5 | We conclude that: (1) Na+-independent Cl-/HCO3- exchange determines steady-state pHi in rat peritoneal mast cells; and (2) the reduction in histamine release observed in the presence of HCO3- is not due to its effect on pHi per se, but rather on other changes in ion transport. | Bicarbonates | glucose-6-phosphate isomerase | Rattus norvegicus |
| 6 | We conclude that: (1) Na+-independent Cl-/HCO3- exchange determines steady-state pHi in rat peritoneal mast cells; and (2) the reduction in histamine release observed in the presence of HCO3- is not due to its effect on pHi per se, but rather on other changes in ion transport. | Bicarbonates | glucose-6-phosphate isomerase | Rattus norvegicus |
| 7 | We conclude that: (1) Na+-independent Cl-/HCO3- exchange determines steady-state pHi in rat peritoneal mast cells; and (2) the reduction in histamine release observed in the presence of HCO3- is not due to its effect on pHi per se, but rather on other changes in ion transport. | Bicarbonates | glucose-6-phosphate isomerase | Rattus norvegicus |